Mea nui: Doxycycline hydrochloride

Nā waiwai: He ʻōmaʻomaʻo māmā kēia huahana.

Nā hana lāʻau lapaʻau:

Pharmacodynamics:ʻO kēia huahana he tetracycline broad-spectrum antibiotic me ka hopena antibacterial ākea ākea. ʻO nā maʻi maʻi maʻalahi e pili ana i nā bacteria Gram-positive e like me ka pneumococcus, streptococcus, kekahi staphylococcus, anthrax, tetanus, corynebacterium a me nā bacteria Gram-negative ʻē aʻe e like me Escherichia coli, Pasteurella, Salmonella, Brucella a me Haemophilus, Klebsiella a me meliobacter. Hiki iā ia ke kāohi iā Rickettsia, mycoplasma a me spirochaeta i kekahi ʻano.

Pharmacokinetics:Hoʻopili wikiwiki ʻia, liʻiliʻi ka hopena o ka meaʻai, bioavailability kiʻekiʻe. Mālama ʻia ke koko kūpono no ka manawa lōʻihi, ikaika ka permeability o ka ʻiʻo, ākea ka puʻupuʻu, a maʻalahi ke komo i ke kelepona. ʻO ka nui o ka puʻunaue ʻana i nā ʻīlio ma kahi o 1.5L/kg. ʻO ka nui o ka hoʻopaʻa ʻana i ka protein no nā ʻīlio 75% a 86%. ʻAʻole i hoʻohana ʻia e ka chelation i loko o ka ʻōpū, 75% o ka nui o ka ʻīlio i hoʻopau ʻia ma kēia ala. ʻO ka hoʻokuʻu ʻana o ka renal he 25% wale nō, ʻoi aku ka liʻiliʻi o ka biliary excretion ma mua o 5%. ʻO ka hapalua o ke ola o ka ʻīlio ma kahi o 10 a 12 mau hola.

Nā pilina lāʻau:

(1) Ke lawe ʻia me ka sodium bicarbonate, hiki ke hoʻonui i ka waiwai pH i ka ʻōpū a hoʻemi i ka absorption a me ka hana o kēia huahana.

(2) Hiki i kēia huahana ke hana i nā mea paʻakikī me nā cations divalent a me trivalent, a pēlā aku, no laila ke lawe ʻia lākou me ka calcium, magnesium, aluminika a me nā antacids ʻē aʻe, nā lāʻau lapaʻau i loko o ka hao a i ʻole ka waiū a me nā meaʻai ʻē aʻe, e hoʻemi ʻia ko lākou absorption. hoemi i ke koko koko.

(3) ʻO ka hoʻohana like me nā diuretics ikaika e like me ka furthiamide hiki ke hōʻeha i ka pōʻino renal.

(4) Hiki ke hoʻopilikia i ka hopena bactericidal o ka penicillin i ka wā hānau bacteria, pono e pale i ka hoʻohana like.

Nā hōʻailona:

ʻO ka maʻi o ka bacteria maikaʻi, ka bacteria maikaʻi ʻole a me ka mycoplasma. ʻO nā maʻi hanu (mycoplasma pneumonia, chlamydia pneumonia, feline nasal branch, feline calicivirus maʻi, canine distemper). Dermatosis, ʻōnaehana genitourinary, maʻi ʻōpū, etc.

Ka hoʻohana a me ka dosage:

Doxycycline. No ka hoʻoponopono kūloko: hoʻokahi pānaʻi, 5 ~ 10mg no 1kg paona kino no nā ʻīlio a me nā pōpoki. Hoʻohana ʻia i hoʻokahi manawa i ka lā no 3-5 mau lā. A i ʻole e like me ka ʻōlelo a ke kauka. Manaʻo ʻia e lawe ma hope o ka ʻai ʻana a me ka inu ʻana i ka wai hou ma hope o ka lawelawe waha.

'Ōlelo Aʻo:

(1) ʻAʻole ʻōlelo ʻia no nā ʻīlio a me nā pōpoki ma lalo o ʻekolu pule ma mua o ka hānau ʻana, lactation, a me 1 mahina o ka makahiki.

(2) E hoʻohana me ka akahele i nā ʻīlio a me nā pōpoki me ka maʻi ʻino o ka ate a me ka puʻupaʻa.

(3) Inā pono ʻoe e lawe i nā mea hoʻohui calcium, nā mea hao hao, nā huaora, nā antacids, ka sodium bicarbonate, a me nā mea ʻē aʻe i ka manawa like, e ʻoluʻolu ma kahi o 2h manawa.

(4) Ua pāpā ʻia ka hoʻohana ʻana me nā diuretics a me ka penicillin.

(5) Hoʻohui ʻia me ka phenobarbital a me ka anticoagulant e hoʻopilikia i ka hana o kēlā me kēia.

Ka hopena ʻino:

(1) I loko o nā ʻīlio a me nā pōpoki, ʻo ka luaʻi, ka maʻi paʻi, a me ka emi ʻana o ka ʻai ʻana i nā hopena ʻino loa o ka doxycycline waha. I mea e hōʻoluʻolu ai i nā hopena ʻino, ʻaʻole i ʻike ʻia kahi emi nui o ka absorption o ka lāʻau i ka wā i lawe ʻia me ka meaʻai.

(2) 40% o nā ʻīlio mālama ʻia he piʻi ka nui o nā enzyme pili i ka hana ate (alanine aminotransferase, conglutinase kumu). ʻAʻole maopopo ke koʻikoʻi o ke kino o ka hoʻonui ʻana i ka hana o ka ate.

(3) Hiki i ka doxycycline waha ke hoʻoulu i ka stenosis esophageal i nā pōpoki, e like me nā papa waha, pono e lawe ʻia me ka liʻiliʻi o 6ml wai, ʻaʻole maloʻo.

(4) Hiki i ka mālama ʻana me ka tetracycline (ʻoi aku ka lōʻihi o ka wā lōʻihi) hiki ke alakaʻi i ka ulu nui ʻana o ka maʻi bacteria a i ʻole nā ​​​​hani (ka maʻi pālua).

Pahuhopu: No nā pōpoki a me nā ʻīlio wale nō.

Hōʻike: 200mg/papa