ʻO Demenidazole, ʻo ia ka hanauna mua o nā lāʻau lapaʻau antigenic, ʻo kona kumukūʻai haʻahaʻa e hoʻohana nui ʻia i ka maʻi lapaʻau lāʻau lapaʻau a me ka mālama ʻana.Eia nō naʻe, me ka hoʻohana nui ʻana i kēia ʻano lāʻau lapaʻau a me ka hoʻi hope a me ka hanauna mua o nitroimidazoles, ʻo ka pilikia o ke kūʻē ʻana i ka lāʻau lapaʻau e ʻike ʻole ʻia.

01Ka hopena anaerobic

Eia nō naʻe, ʻike nui ʻia kāna noi ākea i ka hana ʻana i ka moa i loko o ka bacteria anti anaerobic.I nā makahiki i hala iho nei, ua hoʻohana nui ʻia i ka mālama ʻana i ka moa necrotic enteritis, enterotoxic syndrome a me ka oviduct inflammation.Eia nō naʻe, ke piʻi aʻe nei kona naʻau i nā anaerobes.ʻO ke kumu: no ka manawa lōʻihi i ka wā ma mua, ʻo ka hana ʻino a me ka hoʻohana ʻole ʻia o ia mea ua alakaʻi i ka piʻi ʻana o ke kūʻē ʻana o nā ʻano bacteria anaerobic iā ia i kēlā me kēia makahiki, a ke hoʻomau nei ka nānā ʻana.No ka pale ʻana i kēia ʻano hoʻomohala maikaʻi ʻole, ua pāpā ʻia ka ʻoihana mākaukau o ka lāʻau lapaʻau holoholona ma mua o ʻumi makahiki aku nei: hiki ke hoʻohana wale ʻia i ka hoʻoulu ʻana a me ka hana ʻana i nā holoholona meaʻai nui loa, a hiki ke hoʻohana wale ʻia i loko. ka hānai holoholona a me ka moa, nā holoholona a me nā mea ʻai kūikawā ʻole.

02Hoʻohālikelike ʻepekema a kūpono

Ma ke ʻano o ka hoʻohālikelike ʻana o ka hoʻohana kūpono ʻole o ka demenidazole, ʻo ka mea mua, ʻaʻole pono e hoʻohana pū ʻia me ka methamphenicol, florfenicol a me nā lāʻau antibiotic amido ʻē aʻe, no ka mea hiki i ka demenidazole ke hoʻoulu i ka dysplasia iwi iwi i nā holoholona a me nā moa, a ke hoʻohana pū ʻia me nā mea i luna. ma waena o ka waiʻona antibiotic, e hoʻonui ia i ka hopena o nā hopena ʻino i loko o ke koko.

ʻO ka lua, ʻaʻole pono e hoʻohana ʻia me ka ethanol a i ʻole nā ​​​​mea hoʻomākaukau i loaʻa ka nui o ka ethanol, no ka mea, ʻo ka hui pū ʻana o ia mau mea e hoʻoulu ai i ka hopena disulfiram, a loaʻa paha i nā holoholona maʻi kekahi mau hōʻailona o nā maʻi neurological.Eia kekahi, ʻo ka hoʻohana ʻana i ka waiʻona a i ʻole nā ​​​​lāʻau lapaʻau i loaʻa ka nui o ka waiʻona e pono e hoʻemi ʻia e like me ka hiki i loko o 7-10 mau lā ma hope o ka haʻalele ʻana i ka lāʻau.

ʻO ke kolu, ʻo ka mea nui no ka ʻoihana lapaʻau pipi, ʻo ka mea mua, ʻaʻole pono e hui pū ʻia me nā lāʻau immunosuppressive, inā ʻaʻole, hiki i ka demenidazole ke kāohi i ka hopena o ka mycophenolate mofetil ma ke kino.ʻO ka lua, ʻaʻole hiki ke hoʻohana ʻia me nā anticoagulants waha, kahi e hoʻonui ai i ka hopena anticoagulant o nā anticoagulants waha e like me warfarin, i hiki ai i nā holoholona ke piʻi i ke koko.

ʻO ka mea hope loa, aia kēia ma ka ʻoihana lapaʻau holoholona.ʻO ka mea mua, ʻaʻole hiki ke hoʻohui ʻia me nā mea hoʻopiʻi enzyme lāʻau lapaʻau.No ka laʻana, hiki i nā mea hoʻopiʻi enzyme lāʻau lapaʻau e like me cimetidine ke kāohi i ka metabolism o metronidazole.I ka hui pū ʻana, pono e ʻike i ke ʻano o ka lāʻau lapaʻau koko a hoʻoponopono koke i ke ʻano.ʻO ka lua, ʻaʻole hiki ke hoʻohana ʻia me nā inducers enzyme hepatic drug.I ka hui pū ʻana me nā mea hoʻoheheʻe enzyme hepatic e like me phenytoin, e hoʻolōʻihi ʻia ka metabolism o demenidazole a e hoʻemi ʻia ka ʻike plasma;Ua hoʻolohi ʻia ka metabolism o ka phenytoin a me nā mea hoʻokalakupua o ka enzyme hepatic a ua hoʻonui ʻia ka ʻike plasma.

03Hoʻopili ka hoʻomākaukau i ka hopena curative

No ka mea hiki ke hoʻoheheʻe ʻia ka demenidazole ponoʻī i ka wai a he lāʻau antibiotic e pili ana i ka manawa, ʻo kona mau hemahema lāʻau a me nā ʻano pharmacodynamic e hoʻoholo ai "e hoʻoholo ka hoʻomākaukau i ka pono".ʻIke pinepine mākou i nā ʻāpana mauʻu he ʻilihune loa ka solubility o ka huahana premix dimenidazole.Ma hope o ka hoʻohui ʻana i ka wai nui a hui pū ʻia, aia ka "nui o nā mea hiki ʻole ke hoʻoheheʻe ʻia" i loko o ka hāpana one maikaʻi.ʻAʻole kēia ʻo ka "sophistry" o ka mea hana e kapa ai i ka pilikia o ka maikaʻi o ka wai, a i ʻole ka ʻōlelo wahaheʻe ʻana he mau mea hoʻohui a me nā mea lāʻau ʻole.

ʻO nā huahana premixed a pau o ka dimenidazole, me ka ʻoi aku ka liʻiliʻi a me ka liʻiliʻi, ua hui pū ʻia "ʻaʻohe hopena".

No laila, ʻo ka hapa nui o ka poʻe mahiʻai a me nā mea hoʻohana lāʻau lapaʻau e pono e hoʻolohe i nā huahana "kiʻekiʻe" me ka lawa o ka lāʻau lapaʻau a me ka solubility maikaʻi i ke koho ʻana i nā huahana premix dimenidazole no ka mālama ʻana i nā maʻi anaerobic i ka digestive tract a i ʻole ka ʻōnaehana hānau.Ma waho aʻe o ke koho ʻana i nā lāʻau lapaʻau, ʻo ka hana koʻikoʻi loa: e like me ka pahuhopu maoli o ka hoʻonui ʻana i ka lāʻau kūʻē, pono mākou e hana i kahi hana maikaʻi i ka hui pū ʻana, synergy a me ka hoʻohana ʻana o ka anti drug resistance, i mea e hoʻonui ai a noʻonoʻo i ka "ka maikaʻi" o ka lāʻau lapaʻau.