Loaʻa i nā Sulfonamides nā pono o ka laulā antibacterial spectrum, nā waiwai paʻa, ke kumu kūʻai haʻahaʻa a me nā ʻano hoʻomākaukau like ʻole e koho ai. ʻO ke kumu kumu o sulfonamides he p-sulfanilamide. Hiki iā ia ke keʻakeʻa i ka synthesis o ka waikawa folic bacteria a hoʻopilikia i kona ulu ʻana a me ka hana hou ʻana, no laila ke kāohi nei i ka hapa nui o nā maʻi bacteria Gram-positive a me kekahi mau bacteria maikaʻi ʻole.

ʻO nā maʻi bacteria i paʻakikī loa i ka sulfa: Streptococcus, Pneumococcus, Salmonella, a me nā mea'ē aʻe, a me keʻano maʻalahi: Staphylococcus, Escherichia coli, Pasteurella, Shigella, Listeria, kekahi Actinomyces a me Treponema hyodysenteriae Hoʻopili pū i nā sulfonamides; ʻoi aku ka maikaʻi e kūʻē i kekahi protozoa e like me coccidia. Hiki i ka bacteria pili i ka sulfonamides ke hoʻoikaika i ke kū'ē.

I ka hoʻohana maoli ʻana, hoʻohana pinepine ʻia nā sulfonamides me nā lāʻau lapaʻau ʻē aʻe. ʻO ka hapa nui o nā hopena maikaʻi ʻole o ka hoʻohana lōʻihi ʻana i nā sulfonamides mua he pilikia o ka urinary tract, renal impairment a me ka hoʻemi ʻana i ka ʻai.

I mea e hōʻemi ai i kona ʻona a me nā hopena ʻaoʻao, ʻo ka mea mua, pono ke kūpono, ʻaʻole pono e hoʻonui a hoʻemi ʻia ma ka makemake. Inā ʻoi aku ka nui o ka dosage, e hoʻonui ia i nā mea ʻawaʻawa a me nā hopena ʻaoʻao, a inā he liʻiliʻi loa ka dosage, ʻaʻole ia he hopena therapeutic wale nō, akā e hoʻoulu i ka bacteria pathogenic e hoʻomohala i ka lāʻau kūʻē. ʻO ka lua, e hoʻohana me nā lāʻau lapaʻau ʻē aʻe, e like me ka amproline a me ka sulfonamide synergists, e hōʻemi i ka dosage. ʻO ke kolu, inā ʻae ke kumu, hiki ke hoʻohui ʻia ka nui o ka sodium bicarbonate. ʻO ka hā, hiki i ka bacteria ke hana i nā pae like ʻole o ke kūʻē ʻana i nā lāʻau sulfa, no laila ke kū ʻole lākou i kekahi lāʻau sulfa, ʻaʻole kūpono ke hoʻololi i kekahi lāʻau sulfa. Ma ka ʻōlelo maʻamau, pono e pālua ʻia ka nui o ka lāʻau sulfa, a ma hope o ka manawa koʻikoʻi, pono e koi ʻia ka lāʻau lapaʻau e lawe iā ia no 3-4 mau lā ma mua o ka hiki ke pani ʻia.